Features and Working of Semi-Automated Coagulation Analyzer

What is a Semi-Automated Coagulation Analyzer?

Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.

A machine that enables the testing of blood samples for the blood clotting properties in the individual is a Coagulation Analyzer. Clotting of blood is one of the most important properties. When an individual is hurt, the clotting kicks in to stamp the blood flow by converting it into a gel. In the case of the excessive or insufficient amount of clotting, it can be extremely harmful. Therefore, a need for a coagulation analyzer was recognized to find relevant anomalies and enable quick treatment for the same.

Traditionally, coagulation tests were performed manually and were highly limited in terms of type of tests, accuracy and standardization of results, traceability of results, impact of manual errors etc. Over time, the systems have evolved from almost manual to the automated stage going with the need for higher accuracy, test menu, reproducibility and traceability. One of the best instruments for the testing is the semi-automated coagulation analyzer. Let’s see how it works.

How does Semi-Automated Coagulation Analyzers Work?

The most modern technology available for coagulation analyzers or coagulometers today is the photo-optical detection technology. Consequently, coagulometers or coagulation analyzers that work based on photo-optical detection principles should be the most ideal option for a lab to go for. In this technology, in contrast to a traditional analyzer that utilized magnetic bars with optics to detect clots, this analyzer uses a photo optic method that involves the detection of clots photometrically without the use of magnetic bars.

The coagulation test is performed to calculate factors which are the certain proteins in the blood responsible for the formation of a clot. A person having abnormal coagulation test results might be suffering from Thrombohillia (an excessive amount of clotting and high calculated factor), or Hemophilia (an excessive amount of bleeding and low calculated factor).

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There are two most important coagulation screening tests PT and aPTT. This is based on two different pathways of coagulation intrinsic (aPTT test to measure) and extrinsic (PT test to measure). These tests are to be carried out within four hours of sample procurement. It requires a plasma sample in sodium citrate tubes. All these factors imply the need to offer the test near to the patient itself. Especially as the sample is not stable for long, tests need to be performed soon after sample collection.

In the coagulation testing, PT and aPTT tests are carried out simultaneously to check for bleeding problems or the chances one might have of having too much bleeding during an upcoming surgery. This is usually carried out in hospitals before surgery, to check for liver disease and clotting disorders. In nursing homes, this test is carried out before any surgery. In labs, this test is used as an anticoagulant therapy. The ideal values of aPTT and PT are 25-40 secs and 11-16 secs respectively.

Key Features to look at while going for a coagulation or hemostasis analyzer

  1. Latest photo-optical clot detection technology is better than photo-mechanical technology
  2. No stirrers/bars should needed to improve accuracy and reduce errors and costs
  3. Lower reagent volume (e.g. 50ul for PT) should be considered as it significantly reduces cost per test allowing patient to benefit from low charges
  4. LED technology should be preferred over standard halogen lamps due to their long life
  5. Touch screen interface for user convenience is now a days the standard
  6. Automatic optical start is highly desirable as a dedicated special pipette poses several operational and accuracy challenges
  7. At least 10 sample and 3 reagent positions for incubation must be there
  8. Results in INR, Ratio, Quick % are preferable
  9. Maintenance free instrument with no moving parts is considered better
  10. Compatible with assays such as DDimer is particularly useful feature
  11. Memory of at least 100 patient results must be there
  12. Optional printer connectivity should be there

Read Also: Features and Working of HbA1c Analyzer

Medsource Ozone provides best Semi-Automated Coagulation Analyzers

Medsource Ozone has been following and contributing to the tremendous advances of the industry for a long time now and now offer state-of-the-art machinery for coagulation. This is evident with the best collection of the latest Coagulation Analyzers supplied for the use of numerous hospitals, nursing homes, and laboratories for blood clot testing.

The instruments offered are truly best in class based on Latest clot detection technology, ultralow reagent usage, Touch screen interface, Automatic optical start, LED technology, large number of incubation positions for samples and reagents, choice of 1/2 or 4 channels, no magnetic bars or moving parts, wide menu of reagent compatibility and other host of features.

In the end, the Ozoclot analyzers have stood up to its name and provided the best quality results for efficient decision-making at the time of need in hospitals and nursing homes especially in the cases before surgeries. With Medsource Ozone putting all efforts into enabling prompt and quality delivery and acceptance to the labs and clinics, this analyzer is a great and consistent choice.

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