Products

Microarrays
Traditional karyotyping methods, such as FISH or G-banding, are well established for detecting chromosomal aberrations. However, these methods are limited by speed, throughput and resolution. Our Microarray solutions address these road blocks with focus on clinically relevant results.
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Microarrays
  • ScanRI

      ScanRI

      Fast And Sensitive Scanning With ScanRI - Read more from your array

      One critically important step in the microarray analysis workflow is the generation of high-quality images. ScanRI is a small, easy to use and reliable scanner that meets these criteria. It uses a dual laser confocal system, and provides simultaneous 2-color image acquisition with scanning resolution from 3 μm to 40 μm. As one of the fastest microarray scanners on the market it enables image capture at 3 um resolution in under 30 min. Combined with its small size, low background noise and high sensitivity, ScanRI provides an attractive solution for array users.

      ScanRI Scanner - Main Specifications
      • Weight 15.5 kg
      • Dimensions 278 x 457 x 369 mm3
      • Confocal scanner with integrated autofocus
      • Laser excitation wavelengths of 532 nm and 635 nm
      • Simultaneous 2-color scanning
      • Scanning resolution from 3 μm to 40 μm
      • Two detection photomultipliers and high precision optical filters for enhanced signal-to-noise ratio
      • Suitable for scanning of all standard DNA microarrays and protein arrays (25 mm X 75 mm)

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  • ScanRI HD

      ScanRI HD

      Fast And Sensitive Scanning With ScanRI HD- Read more from your array

      One critically important step in the microarray analysis workflow is the generation of high-quality images. ScanRI HD is a small, easy to use and reliable scanner that meets these criteria. It uses a dual laser confocal system, and provides simultaneous 2-color image acquisition with scanning resolution from 1 μm to 40 μm. Combined with its small size, low background noise and high sensitivity, ScanRI HD provides an attractive solution for array users.

      ScanRI Scanner - Main Specifications
      • Weight 28 kg
      • Dimensions 316 x 549 x 432 mm
      • Confocal scanner with motorized focus adjustment
      • Laser excitation wavelengths of 532 nm and 635 nm
      • Simultaneous 2-color scanning
      • Scanning resolution from 1 μm to 40 μm
      • Two detection photomultipliers and high precision optical filters for enhanced signal-to-noise ratio
      • Suitable for scanning of all standard DNA microarrays and protein arrays (25 mm X 75 mm)

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  • ScanRI HD Autoloader

      ScanRI HD Autoloader

      Fast And Sensitive Scanning With ScanRI HD Autoloader

      One critically important step in the microarray analysis workflow is the generation of high-quality images. ScanRI HD is an easy to use and reliable scanner with autoloader that meets these criteria. It uses a dual laser confocal system, and provides simultaneous 2-color image acquisition with scanning resolution from 1 μm to 40 μm. Combined with its optimum size, low background noise and high sensitivity, ScanRI HD provides an attractive solution for array users.

      ScanRI HD Scanner with Autoloader - Main Specifications
      • Weight 33 kg
      • Dimensions 322 x 656 x 439 mm
      • Confocal scanner with integrated autofocus
      • Laser excitation wavelengths of 532 nm and 635 nm
      • Simultaneous 2-color scanning
      • Scanning resolution from 1 μm to 40 μm
      • Two detection photomultipliers and high precision optical filters for enhanced signal-to-noise ratio
      • Suitable for scanning of all standard DNA microarrays and protein arrays (25 mm X 75 mm)

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  • CGX Onco Arrays

      CGX Onco Arrays

      CGX Onco Arrays are microarrays specifically designed, developed and verified by Signature Genomics for the detection of small genetic aberrations associated with hematological disorders such as leukemias and lymphomas, as well as genes associated with solid tumors. The arrays offer whole genome coverage with specific oncology relevant regions targeted in higher resolution to permit the detection of clinically relevant findings below the detection resolution of conventional karyotyping or FISH analysis. Furthermore, the combination of CGH and SNP probes on the same array allows the detection of copy-number as well as copy-neutral genomic aberrations in one single experiment. The CGX Onco Arrays and reagents, together with the Oncoglyphix software package offer a streamlined and simple analysis workflow for faster and more accurate detection of genomic aberrations in oncology samples.

      Array characteristics that will benefit your work

      • Proven design, representing over 2410 cancer relevant regions based on hg19
      • Coverage of genes present in the CCMC (Cancer Cytogenomics Micorarray Consortium) and Cancer Gene Census  designs, genes cited more recently in the literature, and genes that are family  members of known tumor-related factors (http://www.sanger.ac.uk/genetics/CGP/census/)
      • Combined copy number and LOH detection on the same array
      • Oncoglyphix for fast and streamlined data interpretation

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  • CGX Oligo Arrays

      CGX Oligo Arrays

      CGX Oligo Arrays are oligonucleotide-based microarrays specifically designed for the detection of small genetic aberrations associated with learning disability and dysmorphic features in research applications. The oligonucleotide probes on the CGX™, CGX™-HD and CGX™-SNP arrays cover the entire human genome with specific focus on over 245 cytogenetically relevant regions, 980 functionally significant genes, pericentromeric regions, and subtelomeres. All three array types are based on the same design to provide the laboratory with throughput and detection flexibility. In addition, SNP probes on the CGXTM -SNP arrays allow the detection of Absence of Heterozygosity (AOH) and Uniparental Disomy (UPD).

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  • Genoglyphix Data Visualization Software

      Genoglyphix Data Visualization Software

      Genoglyphix is a powerful data visualization software and database based on the analysis of over 55,000 verified cytogenetic samples.

      DESIGNED BY CYTOGENETICISTS FOR CYTOGENETICISTS

      Genoglyphix offers a proven analysis solution with a complete workflow including sample tracking, aberration categorization, final report creation functionality, and data sharing options with other centres. It also offers the possibility to create userspecific database tracks. Genoglyphix provides intuitive data visualization and annotation features for streamlined, rapid and clear interpretation of CGX data.

      GENOGLYPHIX– BRINGING MULTIPLE GENETIC DATABASES INTO ONE TOOL

      • Access to Signature’s database containing over 14,000 verified genetic alterations identified in over 55,000 samples
      • Direct links to other relevant databases such as the DGV, OMIM, PubMed, UCSC and Ensembl for easy data interpretation
      • Secure web based (128-bit encryption) access to Genoglyphix® database and software


      GENOGLYPHIX EASILY GUIDES CYTOGENETICISTS THROUGH ANALYSIS WITH CONVENIENT TOOLS

      • Generation user defined databases and custom tracks displaying abnormal results, copy number variants and analysis notes
      • Report creation functionality
      • Optional sharing of data with other Genoglyphix® users
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  • CGX Hybridization Oven

      CGX Hybridization Oven

      The CGX™ Hybridization Oven is designed for optimal hybridization performance to achieve consistent and reliable results. The oven is a compact and flexible instrument designed for an optimal microarray processing workflow.

      High Throughput
      Designed to hold up to 24 CGX™ Hybridization Chambers.
       

      Consistent Data
      Reproducible results.
       

      Flexibility
      Variable temperature control range from + 5° to 70°C (+/- 0.1°C) and Variable rotation speed control from 5 to 20 RPM.

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